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October 1974

Toxicity of Octafluorocyclobutane After Intracameral Injection

Author Affiliations

From the Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago.

Arch Ophthalmol. 1974;92(4):324-328. doi:10.1001/archopht.1974.01010010334015

The toxicity and duration of octafluorocyclobutane (C4F8) injected into the anterior chambers of rabbits were compared to those of the same volume of air or sulfur hexafluoride (SF ). A volume of 0.15 ml of C4F8 or SF6 caused increased intraocular pressure, leading to buphthalmos and transitory corneal opacification. Smaller volumes of these gases or 40% mixtures of these gases with air caused minimal toxicity to the anterior chamber structure. The C4F8 consistently lasted longer than SF6 or air.

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