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October 1974

Topically Applied Steroids in Corneal Disease: V. Dexamethasone Alcohol

Author Affiliations

From the Department of Ophthalmology and the Massachusetts Lions Eye Research Laboratory (Drs. Kupferman and Leibowitz), and the Department of Pharmacology, Boston University School of Medicine (Dr. Kupferman), Boston.

Arch Ophthalmol. 1974;92(4):329-330. doi:10.1001/archopht.1974.01010010339016

Topical application of a commercially available aqueous suspension of dexamethasone alcohol, 0.1%, produced measurable quantities of the steroid in both the cornea and in the aqueous humor under all three experimental ocular conditions studied. Drug bioavailability was greatest after removal of the corneal epithelium, but the alcohol derivative of dexamethasone also penetrates through the intact corneal epithelium. Comparison of our present findings with previous experimental data from this laboratory confirms the superiority of an aqueous vehicle over petrolatum ointment for delivering dexamethasone to the eye.

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