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November 1974

Quantitation of Inflammation in the Cornea

Author Affiliations

From the Department of Ophthalmology, Massachusetts Lions Eye Research Laboratory (Drs. Leibowitz and Lass), and the Department of Pharmacology, Boston University School of Medicine (Dr. Kupferman), Boston.

Arch Ophthalmol. 1974;92(5):427-430. doi:10.1001/archopht.1974.01010010439014

Corneal inflammation, produced by direct interlamellar injection of clove oil, is histologically characterized primarily by polymorphonuclear leukocytic infiltration of the stroma. The polymorphonuclear leukocytes can be radiolabelled with tritiated thymidine systemically prior to their invasion of the cornea. A measure of the number of labelled polymorphonuclear leukocytes in the cornea can then be obtained by scintillation counting techniques, which provides an objective method for quantitating the degree of inflammation in the cornea.

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