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December 1974

Microcystic Dystrophy of the Cornea: A Partial Explanation for Its Pathogenesis

Author Affiliations

From the National Eye Institute, Bethesda, Md (Drs. Cogan and Kuwabara, and Ms. Collins), and the Howe Laboratory of Ophthalmology, Harvard Medical School, and Massachusetts Eye and Ear Infirmary, Boston (Dr. Donaldson).

Arch Ophthalmol. 1974;92(6):470-474. doi:10.1001/archopht.1974.01010010484004

Histopathologic examination of the epithelium from a patient with microcystic dystrophy showed an unusual basement insinuating into the midepithelial layer and a consequent entrapment of epithelial cells that are blocked in their forward migration. Ultimate evacuation of the cysts occurs with eventual rupture of the aberrant basement membranes.

Surgical removal of the epithelium is indicated when the symptoms are sufficient to warrant it.

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