Fenoprofen sodium 1% at a pH of 6.4 was found to have comparable efficacy with 0.1% dexamethasone in the topical therapy of an experimental rabbit uveitis model. Increase in pH of fenoprofen to 7.4 resulted in efficacy indistinguishable from the vehicle alone. Since the drug is more ionized at alkaline pH, this decrease in efficacy may have resulted from decreased corneal penetration of a more polarized molecule.
Harris LS, Kahanowicz Y, Hughes J. Ocular Anti-inflammatory Effects of Fenoprofen. Arch Ophthalmol. 1974;92(6):506–508. doi:10.1001/archopht.1974.01010010520012