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December 1974

Ocular Anti-inflammatory Effects of Fenoprofen

Author Affiliations

From the Department of Ophthalmology, New York Hospital—Cornell Medical Center, New York.

Arch Ophthalmol. 1974;92(6):506-508. doi:10.1001/archopht.1974.01010010520012

Fenoprofen sodium 1% at a pH of 6.4 was found to have comparable efficacy with 0.1% dexamethasone in the topical therapy of an experimental rabbit uveitis model. Increase in pH of fenoprofen to 7.4 resulted in efficacy indistinguishable from the vehicle alone. Since the drug is more ionized at alkaline pH, this decrease in efficacy may have resulted from decreased corneal penetration of a more polarized molecule.