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January 1975

Pilocarpine Toxicity: Effects on the Rabbit Corneal Endothelium

Author Affiliations

From the Department of Ophthalmology, Medical University of South Carolina, Charleston, SC.

Arch Ophthalmol. 1975;93(1):36-41. doi:10.1001/archopht.1975.01010020040007

The effects of pilocarpine on the healthy rabbit corneal endothelium were studied by in vitro perfusion, photography, and electron microscopy. The toxicity of endothelial cells to pilocarpine was doserelated. Photography showed shrinkage of cells exposed to pilocarpine. The most striking ultrastructure changes were margination of nuclear heterochromatin and cytoplasmic vacuolation.

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