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January 1975

Teratogenicities of Ophthalmic Drugs: II. Teratogenicities and Tissue Accumulation of Thimerosal

Author Affiliations

From the Department of Ophthalmology, College of Medicine, University of Florida, Gainesville.

Arch Ophthalmol. 1975;93(1):52-55. doi:10.1001/archopht.1975.01010020056010

Under the conditions of this study, systemically or topically applied thimerosal was found to have no teratogenic effect even when given in concentrations approaching the 50% lethal dose of these compounds. A comparison of topical and subcutaneous administration of thimerosal to rabbits shows that a substantial concentration of mercury was present in blood and tissues of the treated animals and their offspring. Thimerosal was found to cross the blood-brain and placenta barriers.

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