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March 1975

Corneal Endothelium in Viral Induced Anterior Uveitis: Ultrastructural Changes Following Canine Adenovirus Type 1 Infection

Author Affiliations

From the Veterinary Virus Research Institute, Research Laboratory for Diseases of Dogs, New York State Veterinary College, Cornell University, Ithaca, NY. Dr. Aguirre is now with the Section of Ophthalmology, University of Pennsylvania School of Veterinary Medicine, Philadelphia.

Arch Ophthalmol. 1975;93(3):219-224. doi:10.1001/archopht.1975.01010020227012

Dogs inoculated intravenously with attenuated canine adenovirus type 1 developed anterior segment inflammation and corneal edema. During the stage of mild anterior uveitis, virus was isolated from the aqueous fluid, and by electron microscopy, viral replication was found to occur in corneal endothelial cells.

Later, at the stage of severe anterior uveitis with corneal edema, virus was not isolated from the aqueous fluid and cells containing intranuclear (replicating) virus were not found. At this stage, many inflammatory cells had infiltrated the anterior chamber and contained numerous membrane-bound viral aggregates (viralantibody complexes). Phagocytized viralantibody complexes were present in the areas of most prominent endothelial cell destruction. Peripheral to the principal lesion sites, inflammatory cells had dissected the endothelium from Descemet membrane. After recovery from the disease, an intact endothelial cell layer was present.

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