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April 1975

Ultrastructure of the Epithelial Dystrophy of Meesmann

Author Affiliations

From the Department of Ophthalmology, New York Hospital-Cornell University Medical Center, New York. Dr. Brown is now at the Eye and Ear Hospital, University of Pittsburgh Medical School, Philadelphia.

Arch Ophthalmol. 1975;93(4):259-263. doi:10.1001/archopht.1975.01010020269004

As in previous studies of Meesmann dystrophy, intense vacuolation of the epithelium was observed. However, neither histochemical nor electron microscopical examination of the specimens showed any evidence of abnormal quantities of glycogen or the electron dense peculiar substance of Kuwabara and Ciccarelli. Electron microscopy indicated that the basic alteration leading to the manifestations of the dystrophy was electron dense bodies in the cytoplasm of the basal epithelial cells. These electron dense bodies appeared similar to lysosomes. In the more superficial cell layers, the electron dense bodies were engulfed by vacuoles that gradually increased in number and size to fill the cytoplasm and, finally, destroyed the most superficial cells.

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