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April 1975

Ocular Penetration in Rabbits of Topically Applied Dexamethasone-Reply

Arch Ophthalmol. 1975;93(4):317. doi:10.1001/archopht.1975.01010020325012

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To the Editor.  —We do not wish to engage in a literary debate with these investigators, and, therefore, do not have a formal reply. However, we do disagree with many of their comments.We thank these investigators for showing a concern in our study. Large differences in results might be explained by our studies being performed in fully awake animals, while Leibowitz and Kupferman used anesthetized animals with altered physiologic and metabolic states. We were happy to see that these investigators provided references to show that dexamethasone sodium phosphate does penetrate the cornea to enter the anterior chamber.While we do not agree with the comments of Drs. Leibowitz and Kupferman, we respect their right to defend their initial studies in their long line of papers on corneal drug penetrations. We are pleased that our article presented enough data and technical descriptions to allow these investigators to write a

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