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May 1975

Circulating Immune Complexes: Effects on Ocular Vascular Permeability in the Rabbit

Author Affiliations

From the University of California School of Medicine, San Francisco.

Arch Ophthalmol. 1975;93(5):365-370. doi:10.1001/archopht.1975.01010020377013

Sudden transient, alteration in vascular permeability is producible in rabbit eyes by intravenous injection of large quantities of antigen, bovine γ-globulin (BGG), into immunized animals or by intravenous injection of large amounts of antigen-antibody complexes (BGG-antiBGG) prepared in antigen excess (20 to 25×) in normal rabbits. Change is measured by ocular accumulation of iodinated l 125 serum albumin, relative to that in heart blood, in intact eyes and separate anatomical compartments, in aqueous, in the anterior eye including (lens plus vitreous), and in the posterior segment. Primarily affected are vessels in the iridial portion of ciliary processes; edema is the primary finding. The same vessels are affected by intravenous injection of bacterial endotoxin, but compared with endotoxin, altered vascular permeability is short-lived and is not associated with formation of platelet plugs and intravenous fibrin strands.

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