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May 1975

Counting Statistics Required for 32P Detection of Choroidal Melanoma-Reply

Arch Ophthalmol. 1975;93(5):391. doi:10.1001/archopht.1975.01010020402022

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To the Editor.  —We are in firm support with Drs. O'Rourke and D'Amato. The 32P test, as it is presently conducted, can be incorrectly interpreted, if inadequate care is excercised in obtaining statistically valid results.Our current methods involved the use of a calculator that can be programmed (Wang 460 with expanded memory and marked sense card reader) in an on-line mode. Counts obtained from a radioactive scaler are entered into the calculator one time only. All statistical maneuvers are performed internally, thus minimizing technician error in the somewhat tedious calculations. The variables examined are (1) the mean and medial percent uptake on randomly paired lesion-control data, (2) percentage error in the samples obtained for the lesion and the control, and (3) a Student range test (P <.05 and P >.01) for the average percent uptake. The calculator thus allows rapid, uniform analysis of the variance in

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