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June 1975

Penetration of Fluorometholone Into the Cornea and Aqueous Humor

Author Affiliations

From the Massachusetts Lions Eye Research Laboratory (Dr. Leibowitz) and the departments of ophthalmology (Dr. Leibowitz) and pharmacology (Dr. Kupferman), Boston University School of Medicine, Boston.

Arch Ophthalmol. 1975;93(6):425-427. doi:10.1001/archopht.1975.01010020439008

In each of the experimental conditions studied, fluorometholone penetrated into the cornea and aqueous humor following topical administration of a standard drop. The amount of drug measured in each location was less than that previously documented for dexamethasone and prednisolone preparations. In contrast to these more conventional steroids, the ocular penetration of fluorometholone appeared to be unaffected by the presence or absence of the corneal epithelium or of intraocular inflammation.

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