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June 1975

Cycloplegics and Mydriatics: Tolerance, Habituation, and Addiction to Topical Administration

Author Affiliations

From the Francis I. Proctor Foundation for Research in Ophthalmology and the Department of Ophthalmology, University of California, San Francisco.

Arch Ophthalmol. 1975;93(6):432-433. doi:10.1001/archopht.1975.01010020446011

A patient had tolerance, habituation, and addiction to the topical use of a combination of cyclopentolate hydrochloride and tropicamide. He also developed a blotchy, diffuse epithelial keratitis that disappeared when the drugs were discontinued.

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