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July 1975

Quinoline Analog Labeled With Iodine 123 in Melanoma Detection

Author Affiliations

From the Medical Research Center (Drs. Packer and Atkins), the Department of Chemistry (Ms. Redvanly and Drs. Lambrecht and Wolf), Brookhaven National Laboratories, Upton, NY, and the Department of Surgery (Ophthalmology), the North Shore University Hospital (Dr. Packer), Manhasset, NY.

Arch Ophthalmol. 1975;93(7):504-508. doi:10.1001/archopht.1975.01010020520007

Using the Greene melanoma In the hamster (Syrian Golden), the radlopharmaceutical, 123I-4(3-dimethylaminopropylamino)-7-iodoquinoline, was tested for Its ability to localize melanoma. This quinoline analog has been described for use in the detection of melanoma, but this Is the first report, to our knowledge, of its being used with an 123I label.

Hamsters with either skin or eye melanomas were studied. Both melanomas could be seen with a gamma camera at three hours after injection. In vitro analysis confirmed the tumor specificity. Thus, it appears that this preclinical trial of a new radiopharmaceutical justifies clinical testing to determine its value in the localization of melanomas of the eyes and skin of humans.

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