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July 1975

Clindamycin and Toxoplasmosis-Reply

Author Affiliations

San Francisco

Arch Ophthalmol. 1975;93(7):546. doi:10.1001/archopht.1975.01010020562031

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In Reply.  —I reviewed with interest the letter that Drs. Parver and Lincoff wrote concerning our article on the use of clindamycin in the treatment of experimentally induced ocular toxoplasmosis. It was gratifying to note that these retinal detachment surgeons observed no adverse effects from the injection of 0.75 ml of clindamycin (150 mg/ml) under the capsule of Tenon at the conclusion of their operative procedures.In a subsequent series of experiments performed by us and accepted for publication in the Archives, we found that subconjunctival injections of 1.0 ml of clindamycin (150 mg/ml) into the anterior segment of the rabbit eye produced severe hyperemia and chemosis of the conjunctiva as well as lid swelling and edema of the subjacent cornea. No such irritation or toxic effects were noted when the material was first diluted so as to contain only 50 mg/ml. Although the results of experiments performed on rabbits

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