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One of the most frustrating moments in the practice of medicine occurs when the physician diagnoses a condition for which the cause is unknown. Ignorance of the true mechanism underlying the disorder partially explains the physician's frustration. Even more important is his sense of inadequacy in planning effective therapy. In many instances, such diseases are those that do not lend themselves to definitive laboratory scrutiny.
Ophthalmologists are well acquainted with disorders of this type. The magnitude of this problem is only too evident when our patients ask us to explain the cause of blinding diseases, such as glaucoma, macular disease, diabetes, uveitis, and retinal detachment. Not only are we unable to answer their questions, we must admit to them that we have no specific treatment for the basic cause of their problem. At best, we offer palliative procedures that attempt, often ineffectively, to cope with side-effects and consequences of the
Brockhurst RJ. Eyes for the Future. Arch Ophthalmol. 1975;93(8):583. doi:10.1001/archopht.1975.01010020567001
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