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August 1975

Retinitis Pigmentosa: A Biomicroscopical Study of Vitreous Abnormalities

Author Affiliations

From the Eye Research Institute of Retina Foundation and the Retina Service, Massachusetts Eye and Ear Infirmary, Boston.

Arch Ophthalmol. 1975;93(8):603-608. doi:10.1001/archopht.1975.01010020583005

A biomicroscopical study of the vitreous body was performed on 116 eyes of 58 patients with primary retinitis pigmentosa, and six additional eyes were examined histopathologically. A characteristic vitreous degeneration, found in all eyes, was clinically divided into four sequential stages that appear to parallel the magnitude of gross retinal destruction as determined by visual-field measurements. The vitreous breakdown in retinitis pigmentosa may be due to progressive loss of hyaluronic acid from the hyaluronic acidcollagen complex.

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