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May 1976

Chorioretinal Heredodegenerations

Arch Ophthalmol. 1976;94(5):873. doi:10.1001/archopht.1976.03910030437022

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Classification of retinal disease has never been easy. Difficulties include variable expressivity of similar diseases, similar expressivity of different diseases, lack of objective physiognomical documentation, and a world literature in a plethora of languages. Add to this a paucity of histopathologic correlations of acute or early disease and a pervasive ignorance of pathophysiology. Previous classifications have been predicated on age of onset (congenital, infantile, pubertal) or affected tissue layer (choriocapillaris, retinal pigment epithelium, retina) or mode of inheritance (autosomal recessive, sex-linked) or etiology (developmental, degenerative, inflammatory, involutional). No single or multiple classification has been satisfactory to date. Now previously described diseases should be correlated with stereoscopic photography, fluorescein and indocyanine green angiography, and selective spectral sensitivity of the intraocular structures and re-evaluated in terms of their electrophysiologic responses, including the computer-averaged electroretinogram and visually evoked response and the use of the electrooculogram. The daily emergence of objective, repeatable information from

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