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July 1976

The Blood-Ocular Barriers Under Osmotic Stress: Studies on the Freeze-Dried Eye

Author Affiliations

From the Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania Medical School, Philadelphia, and the Laboratory of Neurophysiology, National Institutes of Mental Health, Bethesda, Md.

Arch Ophthalmol. 1976;94(7):1086-1091. doi:10.1001/archopht.1976.03910040006002

• Regional differences in the response of primate blood-ocular barriers to severe osmotic stress were measured. Marker dyes were localized by fluorescence microscopy in tissues that had been freeze-dried to prevent diffusion. Under severe osmotic stress, the form and the function of the ciliary process are grossly compromised while the iris is spared. Breakdown of the retinal pigment epithelial barrier is widespread, while the retinal blood vessels in large areas retain normal permeability characteristics. The pigment epithelial barrier mechanism is substantially more susceptible to osmotic stress in the region surrounding the optic disc than in the equatorial area.

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