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July 1976

Penetration of Tobramycin Sulfate in the Aqueous Humor of the Rabbit

Author Affiliations

From the departments of bacteriology-virology and medicine (Dr Uwaydah) and ophthalmology (Dr Faris), American University of Beirut, Beirut, Lebanon.

Arch Ophthalmol. 1976;94(7):1173-1174. doi:10.1001/archopht.1976.03910040081015

• The intraocular penetration of tobramycin sulfate, a new aminoglycoside antibiotic, was evaluated in rabbits following subconjunctival injection. The mean tobramycin sulfate concentration in the aqueous humor 60 minutes after a single 5-mg dose was 5.5 μg/ml, as compared to a mean concentration of 6.7 μg/ml following a single 10-mg dose. These levels exceed the minimal inhibitory concentration (MIC) for most Pseudomonas species and a variety of other Gram-negative bacilli recovered from clinical infection. No anterior segment changes that may be attributed to the antibiotic could be demonstrated in the injected eye.

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