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September 1976

Aqueous Ascorbate Concentration in Hereditary Buphthalmic Rabbits

Author Affiliations

From the Department of Ophthalmology and Biochemistry, Albany Medical College, Albany, NY, and the Jackson Laboratory, Bar Harbor, Me.

Arch Ophthalmol. 1976;94(9):1565-1567. doi:10.1001/archopht.1976.03910040395015

• Some aqueous humor constituents, including ascorbate, protein, and sodium, potassium, and calcium ions, were analyzed in three groups of adult buphthalmic (bu/bu) rabbits from strain AXBU/J and in control rabbits of the closely related strain AX/J.

Aqueous humor ascorbate concentration of the normal strain was 22.5 ± 2.3 mg/100 ml. The buphthalmic rabbits that had no meaningful clinical signs of glaucoma at the time of sample collection had lower values (11.7 ± 1.7 mg/100 ml). Much lower values were observed in the bu/bu mutant rabbits that showed mild to severe glaucoma: 8.9 ± 3.8 mg/100 ml and 1.9 ± 0.4 mg/100 ml, respectively. It was concluded that reduction of aqueous ascorbate is a biochemical change associated with the pathological development of buphthalmia in rabbits of the AXBU/J strain. However, the exact mechanism is still unclear.