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October 1976

Visual Effects of Pilocarpine in Glaucoma: Comparative Study of Administration by Eyedrops or by Ocular Therapeutic Systems

Author Affiliations

From the private ophthalmology practices of Dr Brown, Santa Barbara, Calif, and Dr Meltzer, Denver, Colo, and the Clinical Research Unit, ALZA Corp, Palo Alto, Calif (Drs Merrill and Place and Mss Fisher and Ferré).

Arch Ophthalmol. 1976;94(10):1716-1719. doi:10.1001/archopht.1976.03910040490004

• Eighteen glaucoma patients each received four pilocarpine regimens in random sequence: 1% and 4% eyedrops and 20μg/hr and 40μg/hr ocular therapeutic systems. Unimportant changes in refraction, near vision, and distance vision occurred during the use of either ocular therapeutic system. Miosis with ocular therapeutic systems was almost always less intense and variable than with eyedrops. Refractive changes occurred in 12 patients following 1% pilocarpine and in 16 patients following 4% pilocarpine drops; decreased distance vision occurred in nine patients after 1% drops and in 12 patients after 4% drops. Fewer patients showed decreases in near vision. In all cases, visual effects peaked one half hour after eyedrop instillations and returned gradually toward normal in the next two to three hours. Intraocular pressure levels were within comparable ranges during all four treatments, but the ocular therapeutic systems maintained pressure at a more constant level.

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