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October 1976

Herpes Simplex Virus in Human Cornea, Retrocorneal Fibrous Membrane, and Vitreous

Author Affiliations

From the Department of Cornea Research, Eye Research Institute of Retina Foundation, and the Cornea Service, Massachusetts Eye and Ear Infirmary, Boston.

Arch Ophthalmol. 1976;94(10):1726-1729. doi:10.1001/archopht.1976.03910040500007

• A case of recurrent herpes simplex virus keratouveitis was studied using both electron microscopic and viral culture techniques. We describe a patient who had a particularly violent course, including three failed grafts, endophthalmitis, and wound leak. We report the identification of virus in a quiescent failed corneal graft and retrocorneal membrane; persistence of virus enabling its culture from the vitreous; and electron microscopic identification in the cornea removed at the third transplant.

The identification of cases in which viral proliferation occurs is necessary for a greater understanding of the pathogenesis of herpetic corneal disease and for determining in which particular patient steroid therapy should be avoided.

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