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November 1976

Differential Reactivity of Rabbit Iris and Ciliary Process to Topically Applied Prostaglandin E2(Dinoprostone)

Author Affiliations

From the Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia (Dr Laties); the Department of Ophthalmology and Visual Science, Yale University, New Haven, Conn (Drs Neufeld and Sears); and the Anatomical Institute, University of Oslo (Dr Vegge).

Arch Ophthalmol. 1976;94(11):1966-1971. doi:10.1001/archopht.1976.03910040672015

• The topical application of prostaglandin E2 (dinoprostone) is followed by massiveswelling of the ciliary process, leading to substantial leakage of marker dye into the posterior chamber and directly into the region of the iris, where the primary ciliary processes insert. In contrast, blood vessels of the iris proper retain most of their normal barrier quality and do not leak Evans blue dye.

The adrenergic innervation of the anterior segment remains normal in density and in quality after the topical application of PGE2.

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