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December 1976

Response to Topical Epinephrine: A Practical Prognostic Test in Patients With Ocular Hypertension

Author Affiliations

From the Glaucoma Center, Department of Ophthalmology, Washington University School of Medicine, St Louis.

Arch Ophthalmol. 1976;94(12):2057-2058. doi:10.1001/archopht.1976.03910040717001

• Eighty patients with ocular hypertension (intraocular pressure >20 mm Hg) and GG-response to topical corticosteroids (over 31 mm Hg after six weeks of topical dexamethasone 0.1% four times a day) were tested for ocular hypotensive response to topical epinephrine. Of 80 patients observed for five to ten years, 20 (25%) developed glaucomatous visual field defects, and 34 (43%) were "responders" to topical epinephrine (IOP reduction of greater than 5 mm Hg). Of 20 patients who developed glaucomatous visual field defects, 17 (85%) had responded to topical epinephrine, but only 28% of those who did not have visual field defects showed this type of epinephrine response. Of 34 epinephrine responders, 17 (50%) developed glaucomatous visual field defects as compared to three of 46 (6.5%) nonresponders. The initial applanation IOP level proved less valuable as a prognostic indicator.