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December 1976

Skip Areas in Temporal Arteritis

Author Affiliations

From the Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Conn. Dr Albert is now with the Massachusetts Eye and Ear Infirmary, Boston. Dr Keltner is now with the University of California School of Medicine, Davis.

Arch Ophthalmol. 1976;94(12):2072-2077. doi:10.1001/archopht.1976.03910040732006

• Segments of temporal arteries removed from patients with the characteristic systemic findings of temporal arteritis were studied to determine whether they showed "skip areas" lacking evidence of granulomatous inflammation, as has been frequently described in this disease, or showed diagnostic evidence of inflammation throughout the entire length of the artery. Eleven temporal artery specimens from ten patients were included in this study. Sections from areas of each specimen had previously been found to contain typical granulomatous inflammation. Nine of these biopsy specimens contained granulomatous inflammation throughout their entire length. Two specimens each had two discrete areas of granulomatous inflammation adjoining segments that lacked evidence of epithelioid or giant cells. These "skip areas" showed diffuse round-cell infiltration of the adventia or lacked evidence of inflammation entirely. This series suggests that "skip areas" in temporal arteritis do occur.

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