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January 1977

Intravitreal Amphotericin B Treatment of Candida Endophthalmitis

Author Affiliations

From the Retina and Pathology Services, Department of Ophthalmology, Northwestern University School of Medicine, Chicago.

Arch Ophthalmol. 1977;95(1):89-93. doi:10.1001/archopht.1977.04450010089008

• A 43-year-old heroin addict with Candida albicans endophthalmitis was treated with a single 5-μg intravitreal injection of amphotericin B. The diagnosis was confirmed by smears and cultures of a vitreous aspiration. The patient's accidental death seven weeks after treatment enabled us to obtain histopathologic evidence that the infection had been cured and that the amphotericin B had had no toxic effect on the retina. Intravitreal amphotericin B should be considered an important mode of treatment of Candida endophthalmitis.

(Arch Ophthalmol 95:89-93, 1977)