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In Reply.–We would like to comment on the note by Dr Quigley regarding his and other recent articles that were published after our report was in press. We are very much in agreement with his comments concerning the importance of temperature, freezing duration, and placement of the probe in cyclocryotherapy. It would seem that all of these reports allow a more scientific basis for treatment to be used than was previously available.
We would also like to comment on one further point that neither we nor Dr Quigley dealt with in our articles. Much of the attention in previous studies of cyclocryotherapy has been directed to the effects of the freezing process on the two layers of ciliary epithelium. From the extensive literature on the effects of freezing on living cells, two facts seem well established. For an individual cell, the most critical and damaging time during the freezing