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September 1977

Chloramphenicol Penetration Into Eyes-Reply

Author Affiliations

Little Rock, Ark

Arch Ophthalmol. 1977;95(9):1650. doi:10.1001/archopht.1977.04450090172020

In Reply.—We agree with Green and MacKeen that drug contact time with the eye following topical administration is important for drug penetration,1 and that the surface epithelium of the eye acts as a reservoir for drug storage, as well as a barrier to drug penetration.2 We do not agree that a comparison between their study, where a 50 μl drop of chloramphenicol solution was placed in the eye and the lids were held apart to form a reservoir for up to four hours,1 can be made with our study, where 50 μl of ointment was placed in the eye and the eye was bandaged.3 We interpreted the 50-μl drop in the held open eye as bathing because the normal rabbit (and man4) lacrimal fluid volume is 7.5 ± 2.5 μl.5 Only a fraction of this 7.5 μl would remain after 30 minutes of

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