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October 1977

Methyl Alcohol Poisoning: III. Ocular Toxicity

Author Affiliations

From the Departments of Ophthalmology (Drs M. Hayreh and S. Hayreh) and Pathology (Drs Baumbach and Cancilla), and the Toxicology Center, Department of Pharmacology (Drs Martin-Amat, Tephly, and Makar, and Mr McMartin), College of Medicine, University of Iowa, Iowa City.

Arch Ophthalmol. 1977;95(10):1851-1858. doi:10.1001/archopht.1977.04450100153022

• The ocular toxicity of methyl alcohol has been investigated in six rhesus monkeys. All the animals developed fundus changes within 43 to 171 hours after its ingestion. The only fundus lesion seen was optic disc edema and associated changes, usually of a marked degree. Fluorescein fundus angiography confirmed the findings. The retinal and choroidal circulations, including the retinal capillary bed, were normal. Ophthalmoscopically and angiographically, optic disc edema in methyl alcohol poisoning was Indistinguishable from that seen in raised intracranial pressure, except that no increased intracranial pressure was observed. It is postulated that optic disc edema in methyl alcohol poisoning is due to an axoplasmic flow stasis.

(Arch Ophthalmol 95:1851-1858, 1977)

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