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October 1977

Endocrine Influences on Ulceration and Regeneration in the Alkali-Burned Cornea

Author Affiliations

From the Department of Ophthalmology, University of North Carolina, School of Medicine, Chapel Hill. Dr Crabb is now in private practice in Winston-Salem, NC.

Arch Ophthalmol. 1977;95(10):1866-1870. doi:10.1001/archopht.1977.04450100168024

• Subconjunctival dibutyryl 3′,5′ cyclic adenosine monophosphoric acid (DBcAMP) produced a statistically significant reduction of ulceration in the alkaliburned rabbit cornea. No effect on epithelial cell growth was observed. DBcAMP also caused a statistically significant acceleration of corneal neovascularization in the first two weeks postburn. Medroxyprogesterone acetate also affected the development of corneal ulcers postalkali burn, but in a less well-defined manner. Dinoprost and indomethacin did not seem to influence this lesion. Cyclic adenosine monophosphoric acid may therefore possess a potential for use in the alkali-burned human eye.

(Arch Ophthalmol 95:1866-1870, 1977)

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