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November 1977

Café-au-Lait Spots of the Fundus in Neurofibromatosis

Author Affiliations

From the Departments of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago, and State University of New York at Buffalo.

Arch Ophthalmol. 1977;95(11):1990-1992. doi:10.1001/archopht.1977.04450110084007

• Mild pigmentary changes found in the fundi of two patients with neurofibromatosis, resembled café-au-lait spots homologous with skin manifestations of the disease. In one, associated retinal hamartomas were present. The café-au-lait lesions were clinically distinct from previously reported uveal melanomas and may represent a hitherto unrecognized sign of ocular neurofibromatosis.

(Arch Ophthalmol 95:1990-1993, 1977)

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