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November 1977

Clinical Comparison of 10% and 25% Intravenous Sodium Fluorescein Solutions

Author Affiliations

From the Cullen Eye Institute, Baylor College of Medicine, Houston (Mr Justice and Dr Paton), and Suffolk Ophthalmology Associates, Bay Shore, NY (Dr Beyrer and Mr Seddon).

Arch Ophthalmol. 1977;95(11):2015-2016. doi:10.1001/archopht.1977.04450110109013

• Sodium fluorescein solutions, 3 ml of 25% solution and 5 ml of 10% solution, were compared with a double-blind crossover method in a group of 41 normal volunteers and in a group of 42 patients who had diverse ophthalmic disorders. Following injection of the solutions into the antecubital vein, visualization, serial fluorescein angiograms, and five-minute phase angiograms were studied and compared.

The untoward reactions reported in both studies were of types usually associated with sodium fluorescein, the most common of which was a mild, transient nausea. On the basis of our results, there is no significant difference in the incidence and severity of adverse reactions between the 10% and 25% solutions.

In the volunteer study, the 25% solution was significantly superior in visualization and paired comparison (P <.001). In the patient study, the 25% solution was significantly superior in angiogram quality (p <.01), five-minute phase angiogram (p <.05), and paired comparison (p <.005).

The overall superiority of the 25% concentration in a 3-ml volume was demonstrated both subjectively and objectively in the volunteer study and in the patient study.

(Arch Ophthalmol 95:2015-2016, 1977)