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February 1978

Immunosuppressive Therapy for Severe Chronic Uveitis

Author Affiliations

From the Divisions of Immunology, Allergy, and Rheumatology and the Department of Ophthalmology, University of Oregon Health Sciences Center, Portland.

Arch Ophthalmol. 1978;96(2):247-251. doi:10.1001/archopht.1978.03910050115002

• Twenty-five patients with severe, progressive, chronic uveitis who were poorly responsive or unresponsive to corticosteroid therapy received low-dose prednisone and cytotoxic immunosuppressive therapy. Azathioprine (2.0 to 2.5 mg/kg) or chlorambucil (6 to 8 mg) was combined with prednisone (10 to 15 mg) daily in a long-term therapeutic program. All 25 patients exhibited a therapeutic response. In 18 of 25 patients, complete quiescence of the inflammatory process was observed. The remaining seven patients showed a substantial decrease of uveitis with persistence of some inflammatory changes. Adverse side effects that resulted from this therapy were infrequent.

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