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May 1978

More Chloramphenicol in Your Eye

Author Affiliations

Augusta, Ga
Washington, DC

Arch Ophthalmol. 1978;96(5):912. doi:10.1001/archopht.1978.03910050508032

To the Editor.  —Recent correspondence in the Archives concerning methods of drug administration and the interpretation of data thereby obtained,1,2 suggests that a gross misinterpretation of our methodology has occurred.1,3To correct any possible future errors of interpretation of the original study,4 we present the procedural steps that were followed in our experiments in as simple a manner as possible as follows:

  1. The rabbit lids were gently held apart with the rabbit sitting in a normal position on a bench.

  2. A 50μl drop was placed on each cornea and allowed to flow over the corneal surface.

  3. The eyelids were released, and the rabbit was allowed to blink normally until time for sampling.

  4. At various intervals following drop instillation, the animal was turned onto its left side, and the lids of the right eye were held apart to form a conjunctival cup.

  5. Distilled water

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