• Nine family members with hereditary retinal neovascularization showed wide variability in the extent of the clinical disorder and a slow progression of the disease process. Clinical and angiographic evaluation of these patients at various stages of their disease, and analysis of their histories points to a progressive peripheral retinal vascular disorder with secondary vitreous changes. The condition is characterized by retinal arteriolar ischemia, new vessel formation at the retinal periphery, and hemorrhage with retinal detachment.
Gitter KA, Rothschild H, Waltman DD, Scott B, Azar P. Dominantly Inherited Peripheral Retinal Neovascularization. Arch Ophthalmol. 1978;96(9):1601–1605. doi:10.1001/archopht.1978.03910060235009