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September 1978

The Pathogenesis of Nerve Damage in Glaucoma: Contributions of Fluorescein Angiography

Arch Ophthalmol. 1978;96(9):1709. doi:10.1001/archopht.1978.03910060307032

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This is one of the publications in the series Current Ophthalmology Monographs introduced by Grune & Stratton Inc. This monograph is based on the author's interpretation of the fluorescein fundus angiograms in 247 patients. Included in this study were normal control subjects (50); patients suspected of having glaucoma (87); patients with primary open-angle glaucoma (62); patients with lowtension glaucoma (16); and patients with other types of glaucoma (32). These patients were followed up for periods of up to five years.

The author concluded that his study showed the existence of considerable differences between control subjects and patients with chronic open-angle glaucoma in regard to blood flow to the optic nerve and retina. Elevation of intraocular pressure caused retardation of the rate of flow in the retina, optic nerve, and possibly choroid. Perfusion of the optic nerve, as determined by fluorescein fundus angiography, was more severely affected in some cases by

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