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October 1978

Posterior Keratoconus

Author Affiliations

From the Iowa Lions Cornea Center, Department of Ophthalmology, University of Iowa Hospitals, Iowa City (Dr Krachmer), and the Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, Md (Dr Rodrigues).

Arch Ophthalmol. 1978;96(10):1867-1873. doi:10.1001/archopht.1978.03910060371016

• Posterior keratoconus is a rare corneal disorder characterized by a total or localized noninflammatory thinning of the cornea. In front of a conical protrusion of the posterior corneal curvature, there is a thinned stroma and nonprotruding anterior surface. A corneal button from a patient with bilateral posterior keratoconus was studied by light and electron microscopy. Descemet's membrane, particularly in the area of stromal thinning, demonstrated abnormal anterior banding, a multilaminar configuration, and localized posterior excrescences. These alterations suggest an early pathogenetic mechanism, which probably originated prior to the fifth or sixth month of gestation.