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January 1979

Mean Circulation Time of Fluorescein in Retinal Vascular Segments

Author Affiliations

From the Department of Retina Research, Eye Research Institute of Retina Foundation (Drs Eberli, Riva, and Feke), and the Department of Ophthalmology, Harvard Medical School (Drs Riva and Feke), Boston.

Arch Ophthalmol. 1979;97(1):145-148. doi:10.1001/archopht.1979.01020010079018

• Mean circulation time (MCT) of sodium fluorescein in retinal vascular segments was determined in healthy human volunteers, using the dye dilution technique. The fluorescein dilution curves were recorded with a two-point fluorophotometer. Average MCT was 3.9 seconds. The accuracy of the method was determined from repeated measurements in owl monkeys and human volunteers. No significant linear correlation was found between the MCT and the cross section of the vessels feeding and those draining the segment. The application of this technique to clinical work is discussed, and is illustrated by three clinical cases.

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