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April 1979

Combined Amphotericin B and Rifampin Treatment of Experimental Candida albicans Keratitis

Author Affiliations

From the Francis I. Proctor Foundation for Research in Ophthalmology and the Department of Ophthalmology, University of California, San Francisco. Dr Stern is now with the Department of Ophthalmology, George Washington University School of Medicine, Washington, DC.

Arch Ophthalmol. 1979;97(4):721-722. doi:10.1001/archopht.1979.01020010373020

• In a model of experimental Candida albicans keratitis in rabbits, treatment with a combination of amphotericin B and rifampin was compared with treatment with amphotericin B alone. Both modes of therapy substantially reduced the number of organisms in the cornea below the number in untreated control corneas. In the group treated with combined therapy, there were significantly fewer organisms in the cornea after three days of therapy than in the group treated with amphotericin B alone. The results of this study indicate that the treatment of C albicans keratitis in rabbits with combined amphotericin B and rifampin is more effective than treatment with amphotericin B alone.

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