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June 1979

Misinterpretation of la Maladie du Greffon

Arch Ophthalmol. 1979;97(6):1177. doi:10.1001/archopht.1979.01020010625025

To the Editor.  —In the article "Subepithelial Infiltrates: A Probable Sign of Corneal Transplantation Rejection" in the December 1978 issue of the Archives (96:2234-2237), the authors refer to the classic monograph of Paufique et al, "Les Greffes de la Cornée." This monograph is an excellent work and contains many innovative surgical techniques and astute clinical observations on the reasons for the success or failure of corneal transplants. However, the concept that has been most frequently misquoted from this monograph is la maladie du greffon. This was done again in the centennial issue of the Archives. I quote from that issue: "The corneal graft rejection was first described by Paufique et al in 1948." They then proceed at the end of the paragraph to state, "An allergic reaction to the transplanted tissue was the proposed pathogenesis."Because of our subsequent knowledge, I assume Krachmer and Alldredge were crediting Paufique and his

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