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July 1979

A Systematic Comparison of Chemically Induced Eye Injury in the Albino Rabbit and Rhesus Monkey

Arch Ophthalmol. 1979;97(7):1372-1373. doi:10.1001/archopht.1979.01020020096028

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This book presents the results of extensive studies performed at the Hazleton Laboratories America in Vienna, Va, under the supervision of the senior author, who is an ophthalmologist and pathologist at the Johns Hopkins University School of Medicine, Baltimore. Important differences exist between rabbit and primate eyes in response to chemical irritants and in their capacity to recover from the insult. The chemical materials selected were representative of substances that have been introduced accidentally or deliberately into the human eye. The principal chemicals investigated were soap, synthetic surfactants, and alkaline salts. Included also were sodium hydroxide, sulfuric acid, sodium chloride, and silver nitrate.

The rabbit eye proved to more sensitive than the monkey eye to injury by most chemicals. The exception was 5% sulfuric acid. Results of histopathologic examinations confirmed and further delineated structural changes detected by biomicroscopy. Irrigation of the eye two minutes after instillation of a chemical usually

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