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November 1979

Optimal Frequency of Topical Prednisolone Administration

Author Affiliations

From the Departments of Ophthalmology (Drs Leibowitz and Kupferman) and Pharmacology (Dr Kupferman), Boston University School of Medicine.

Arch Ophthalmol. 1979;97(11):2154-2156. doi:10.1001/archopht.1979.01020020472014

• The relationship between the frequency with which 0.125% and 1.0% prednisolone acetate ophthalmic suspensions are instilled and the anti-inflammatory effect they achieve in the cornea was studied. Within the time limits of the experimental protocol, application of the drug at four-hour intervals failed to produce an effect while hourly administration of both concentrations of the corticosteroid produced a substantial anti-inflammatory effect. Instillation at 15-minute intervals resulted in a significantly (P < .05) greater reduction of the polymorphonuclear leukocytes invading the cornea than did administration of the medication every hour. If five doses of prednisolone acetate were applied topically at one-minute intervals each hour, both concentrations of this corticosteroid produced a therapeutic effect in the cornea equal to that achieved by administration of the drug every 15 minutes.

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