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February 1980

Identification of Crystalline Deposits-Reply

Author Affiliations

Bethesda, Md

Arch Ophthalmol. 1980;98(2):386. doi:10.1001/archopht.1980.01020030382032

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In Reply.  —The diagnosis of monoclonal gammopathy was established by urine and serum immunoelectrophoresis, but not on the basis of immunoperoxidase stains of the corneal tissue. The article stated that the corneal deposits stained with antiserum to immunoglobulins IgG, IgA, IgM, and κ light chains (page 126). In addition, λ light chain staining was also positive. It is possible that the deposits could be related to rheumatoid-factor-like activity, although the serum rheumatoid factor determination was negative. The patient has a benign gammopathy at this time, with normal results of bone marrow and roentgenographic studies. However, careful follow-up is indicated.

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