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March 1980

Combined Gentamicin-Tobramycin-Corticosteroid Treatment: II. Effect on Gentamicin-Resistant Pseudomonas Keratitis

Author Affiliations

From the Francis I. Proctor Foundation for Research in Ophthalmology and Department of Ophthalmology, University of California San Francisco.

Arch Ophthalmol. 1980;98(3):473-474. doi:10.1001/archopht.1980.01020030469004

• In an experimental model of Pseudomonas keratitis produced by a gentamicin sulfate-resistant, tobramycin sulfate-sensitive strain of P aeruginosa, the results of two treatment regimens—(1) with gentamicin and tobramycin alone and (2) with gentamicin, tobramycin, and a steroid—were evaluated. All of the animals exhibited ultimately the same amount of corneal inflammation and corneal scarring. In the group receiving the antibioticsteroid combination, the corneal lesions healed more slowly.

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