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March 1980

Keratitis due to Acanthamoeba castellani: A Clinicopathologic Case Report

Author Affiliations

From the Eye Pathology Laboratory, Wilmer Ophthalmological Institute, and Department of Pathology, Johns Hopkins Medical Institutions, Baltimore (Dr Green); Medical Research Service, Veterans Administration Medical Center, Gainesville, Fla (Drs Willaert and Stevens); and Departments of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville (Dr Stevens). Drs Key and Key are in private practice in Austin, Tex.

Arch Ophthalmol. 1980;98(3):475-479. doi:10.1001/archopht.1980.01020030471005

• Trophozoites and cysts of amebas were found within the necrotic cornea of an enucleated eye. The organism was identified, by indirect immunofluorescent staining using specific antiserum, to be Acanthamoeba castellani. This case report illustrates the difficulty of clinical diagnosis and typical inefficacy of medical therapy shown in other reports of this rare keratitis.

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