• Six consecutive patients with early Fuchs' heterochromic cyclitis (FHC) were examined with anterior segment 10% fluorescein sodium angiography. Anterior segment perfusion defects and iris vasculature leakage were seen in all patients. Chronic anterior segment ischemia may be an integral feature of FHC, which predisposes these eyes to rubeosis and, in some cases, to neovascular glaucoma.