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April 1980

Reclassification of Intraocular Reticulum Cell Sarcoma (Histiocytic Lymphoma): Immunologic Characterization of Vitreous Cells

Author Affiliations

From the Retina Service, Department of Ophthalmology (Drs Kaplan, Meredith, and Aaberg) and the Section of Hematology, Department of Medicine (Dr Keller), Medical College of Wisconsin, and the Molecular Immunology Laboratory, Research Service, Wood Veterans Administration Medical Center, Milwaukee (Dr Keller). Dr Kaplan is now with the Emory University Clinic, Atlanta.

Arch Ophthalmol. 1980;98(4):707-710. doi:10.1001/archopht.1980.01020030701010

• Systemic and orbital reticulum cell sarcomas (RCSs) have been shown to be derived from lymphocytes, not reticulum cells or histiocytes, by immunologic and cytochemical characterization. Unfortunately, until now it has not been technically possible to study intraocular RCS. We have been able to immunologically characterize a primary intraocular RCS in a patient with chronic lymphocytic leukemia (ie, Richter's syndrome), establishing its origin from B lymphocytes. A review of the clinical course of such tumors indicates that primary intraocular non-Hodgkin's lymphoma is usually a manifestation of a systemic neoplasm of the immune system.

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