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June 1980

Acetazolamide Dosage Forms in the Treatment of Glaucoma

Author Affiliations

From the Glaucoma Consultation Service, Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston.

Arch Ophthalmol. 1980;98(6):1051-1054. doi:10.1001/archopht.1980.01020031041005

• Patients with chronic glaucoma had a carefully scheduled series of intraocular pressure measurements before and after taking acetazolamide for one week at the following dosages: none, 500 mg of sustained-release capsules once a day, 500 mg of capsules twice a day, and 250 mg of tablets four times a day. A capsule taken once a day, which is better tolerated than one taken twice a day by some patients, offers a substantial pressure-lowering effect that lasts at least 23 hours, although the magnitude of the pressure lowering is less than with higher dosages. One capsule twice a day appears to be as effective in the regulation of IOP as one tablet four times a day. The 45% reduction in outflow pressure is achieved with an acetazolamide serum concentration in the range of 15 to 20 μg/mL.

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